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|Product Name||PIH1D1, 1-290aa, Human|
|Background||PIH1 domain-containing protein 1, also known as PIH1D1, is a phylogenetically conserved protein essential for efficient processing of pre-rRNA through its association with a class of small nucleolar RNAs (snoRNAs) during ribosomal biogenesis. SnoRNAs are associated in ribonucleoprotein particles localized to the nucleolus. PIH1D1 may also function as a novel modulator of apoptosis pathway. Recombinant human PIH1D1 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMANPKLL GMGLSEAEAI GADSARFEEL LLQASKELQQ AQTTRPESTQ IQPQPGFCIK TNSSEGKVFI
NICHSPSIPP PADVTEEELL QMLEEDQAGF RIPMSLGEPH AELDAKGQGC TAYDVAVNSD FYRRMQNSDF LRELVITIAR EGLEDKYNLQ
LNPEWRMMKN RPFMGSISQQ NIRSEQRPRI QELGDLYTPA PGRAESGPEK PHLNLWLEAP DLLLAEVDLP KLDGALGLSL EIGENRLVMG
GPQQLYHLDA YIPLQINSHE SKAAFHRKRK QLMVAMPLLP VPS
|Molecular Weight||15.0 kDa (130aa) confirmed by MALDI-TOF|
|Concentration||1mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT|
|Purity||> 85% by SDS-PAGE|
|NCBI Accession #||NP_060386|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Gonzales F A., et al. (2005) J Mol Biol. 346:437-455.
Granato D C., et al. (2005) FEBS J. 272:4450-4463.
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