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|Product Name||PPP1R8, 1-351aa, Human|
|Background||PPP1R8, also as known as NIPP-1, is the RNA-binding subunit of a major species of protein phosphatase-1 in the nucleus. This enzyme is inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. Recombinant human PPP1R8 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||Nuclear inhibitor of protein phosphatase 1, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047|
|Amino Acid Sequence||MAAAANSGSS LPLFDCPTWA GKPPPGLHLD VVKGDKLIEK LIIDEKKYYL FGRNPDLCDF TIDHQSCSRV HAALVYHKHL KRVFLIDLNS THGTFLGHIR LEPHKPQQIP IDSTVSFGAS TRAYTLREKP QTLPSAVKGD EKMGGEDDEL KGLLGLPEEE TELDNLTEFN TAHNKRISTL TIEEGNLDIQ RPKRKRKNSR VTFSEDDEII NPEDVDPSVG RFRNMVQTAV VPVKKKRVEG PGSLGLEESG SRRMQNFAFS GGLYGGLPPT HSEAGSQPHG IHGTALIGGL PMPYPNLAPD VDLTPVVPSA VNMNPAPNPA VYNPEAVNEP KKKKYAKEAW PGKKPTPSLL IVEHHHHHH|
|Molecular Weight||29.7 kDa (256aa), confirmed by MALDI-TOF|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_054829|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Jin Q., et al. (1999) Biochem. J. 342:13-19
Beullens M., et al. (2000) Biochem. J. 352:651-658
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