PRL-3, 1-173aa, Human, Recombinant

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01-2175-3
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Proteins, Recombinant
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Product Name PRL-3, 1-173aa, Human, Recombinant
Background Protein tyrosine phosphatase type IVA 3 (PRL-3), as known as PTP4A3, belongs to a small class of prenylated protein tyrosine phosphatases (PTPs) that remove phosphate modifications from tyrosine residues on proteins. This protein enhances cell proliferation, cell motility and invasive activity. High levels of PRL-3 expression are associated with tumorigenesis and metastasis, thus it is overexpressed in metastatic colorectal, ovarian, liver and skin cancers. Recombinant human PRL-3, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Synonyms PTP4A3, PRL3, Protein tyrosine phosphatase type IVA 3 Potentially prenylated protein tyrosine phosphatase, PRL 3, PRL R, PRLR, Protein tyrosine phosphatase 4a3, PTP 4A3, Protein Tyrosine Phosphatase Type IVA Member 3
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM
Endotoxin Level < 1.0 EU per 1 microgram of protein (determined by LAL method )
Molecular Weight 23.9 kDa (207aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT.
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_116000
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Ooki A., et al. (2009). Oncol Rep. 21(6):1467-75
Wang Z., et al. (2009). Ann Surg Oncol. 16(1):208-19.

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