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|Product Name||Prostagladin E synthase 3, 1-160aa, Human|
|Background||Prostaglandin E synthase 3 (PTGES3), also known as P23 or TEBP (Telomerase binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. This protein is a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Recombinant PTGES3 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||PTGES3, cPGES, P23, TEBP, HSP90 co-chaperone, Sid 3177, Co chaperone p23, Hsp90 co chaperone, Cytosolic prostaglandin E2 synthase, Progesterone receptor complex, Progesterone receptor complex p23, Prostaglandin E synthase 3, PTGES 3, Telomerase binding protein p23, Unactive progesterone receptor 23 kD,|
|Amino Acid Sequence||MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE|
|Molecular Weight||28.1 kDa (238aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer ( pH8.0) containing 1mM DTT, 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_006592|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Hawkins GA., et al. (2009) J Allergy Clin Immunol. 123(6):1376-83.e7
Nuttinck F., et al. (2008) Reproduction. 135(5):593-603.
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