Prostagladin E synthase 3, 1-160aa, Human

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01-2188
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Proteins, Recombinant
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Product Name Prostagladin E synthase 3, 1-160aa, Human
Background Prostaglandin E synthase 3 (PTGES3), also known as P23 or TEBP (Telomerase binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. This protein is a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Recombinant PTGES3 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms PTGES3, cPGES, P23, TEBP, HSP90 co-chaperone, Sid 3177, Co chaperone p23, Hsp90 co chaperone, Cytosolic prostaglandin E2 synthase, Progesterone receptor complex, Progesterone receptor complex p23, Prostaglandin E synthase 3, PTGES 3, Telomerase binding protein p23, Unactive progesterone receptor 23 kD,
Species Human
Amino Acid Sequence MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE
Molecular Weight 28.1 kDa (238aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl buffer ( pH8.0) containing 1mM DTT, 10% glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_006592
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Hawkins GA., et al. (2009) J Allergy Clin Immunol. 123(6):1376-83.e7
Nuttinck F., et al. (2008) Reproduction. 135(5):593-603.

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