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|Product Name||PSG5, 35-335aa, Human|
|Background||PSG5 is a member of the PSG family, a group of closely related secreted glycoproteins that are highly expressed in fetal placental syncytiotrophoblast cells. PSGs become detectable in serum during the first two to three weeks of pregnancy and increase as the pregnancy progresses, eventually representing the most abundant fetal protein in the maternal blood at term. PSG5 function to stimulate secretion of TH2-type cytokines from monocytes, and they may also modulate the maternal immune system during pregnancy, thereby protecting the semi-allotypic fetus from rejection. Recombinant human PSG5 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Synonyms||Pregnancy-specific beta-1-glycoprotein 5, FL-NCA-3, PSG|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSQVTIEAL PPKVSEGKDV LLLVHNLPQN LAGYIWYKGQ LMDLYHYITS YVVDGQINIY GPAYTGRETV YSNASLLIQN VTREDAGSYT LHIIKRGDRT RGVTGYFTFN LYLKLPKPYI TINNSKPREN KDVLAFTCEP KSENYTYIWW LNGQSLPVSP RVKRPIENRI LILPSVTRNE TGPYECEIRD RDGGMRSDPV TLNVLYGPDL PSIYPSFTYY RSGENLYLSC FAESNPPAEY FWTINGKFQQ SGQKLSIPQI TTKHRGLYTC SVRNSATGKE SSKSMTVEVS APSGIGRLPL LNPI|
|Molecular Weight||35 kDa (315aa), confirmed by MALDI-TOF
(Molecular size on SDS-PAGE will appear higher)
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% glycerol, 1mM DTT.|
|Purity||> 80% by SDS-PAGE|
|NCBI Accession #||NP_001123486|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Chan W Y., et al. (1991) Mol Cell Biochem.106:161-170
Panzetta Dutari G M., et al. (2000) Biochem J. 2:511-519.
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