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|Product Name||PTEN, 1-403aa, Human, Recombinant|
|Background||PTEN, also known as phosphatase and tensin homolog, is a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein acts as both a dual-specificity protein phosphatase and a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. PTEN negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. Recombinant PTEN protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||BZS, MHAM, MMAC1, PTEN1, TEP1, Phosphatase and tensin homolog, PTEN, PTEN1, mutated in multiple advanced cancers 1,|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKFMY FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHTQI TKV|
|Molecular Weight||23.1 kDa (204 aa), confirmed by MALDI-TOF.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in Phosphate Buffered Saline (pH7.4) containing 10% glycerol|
|Purity||> 85% by SDS-PAGE|
|NCBI Accession #||NP_000305|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Li DM., et al. (1997) Cancer Res. 57(11):2124-9.
Maehama T., et al. (1998) J Biol Chem. 273(22):13375-8.
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