PTGDS, 23-190aa, Human

Proteins, Recombinant
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Product Name PTGDS, 23-190aa, Human
Background Prostaglandin-H2 D-isomerase, also known as PTGDS, is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a beta-amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease. Recombinant human PTGDS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms Prostaglandin-H2 D-isomerase, L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2
Species Human
Molecular Weight 14.0kDa (127aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Concentration 0.5mg/ml (determined by BCA)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 200mM NaCl
Purity > 90% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_000945
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Hoffmann A., et al. (1993) J Neurochem. 61(2):451-6.
Giacomelli S., et al. (1996) Biochem Biophys Acta. 1310(3):269-76.

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