PTTG1, 1-202aa, Human, Recombinant

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01-2142
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Proteins, Recombinant
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Product Name PTTG1, 1-202aa, Human, Recombinant
Background PTTG1, also known as Securin, is primarily involved in the regulation of sister chromatid separation during cell division. It has two identified roles; the first one is to help the transport of separase(cysteine protease) to the nucleus and the second role is to inhibit the catalytic activity of separase. It is ubiquitinated by the Anaphase Promoting Complex (APC), and then degraded by the Proteasome, releasing separase. Recombinant PTTG1 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms EAP1, HPTTG, PTTG, TUTR1, SECURIN, Pituitary tumor-transforming protein 1 ESP1 ASSOCIATED PROTEIN 1, Esp1-associated protein, MGC126883, MGC138276, Pds1, PTTG1 protein, PTTG1, Pituitary tumor transforming 1, PTTG 1, EAP 1, Cut2, Pituitary tumor transforming protein 1, AW555095, Pituitary tumor-transforming 1, isoform CRA_a, Pituitary tumor-transforming 1, isoform CRA_b, hPTTG, Pituitary tumor-transforming gene 1, TUTR 1, Pttg3, Pituitary tumor-transforming gene 1 protein, C87862, TUMOR TRANSFORMING 1, Tumor transforming protein 1,
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MATLIYVDKE NGEPGTRVVA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ SPSSILSTLD VELPPVCCDI DI
Endotoxin Level < 0.5 EU per 1 microgram of protein (determined by LAL method)
Molecular Weight 17.1 kDa (152aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH7.5) containing 1mM DTT, 10% glycerol
Purity > 80% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_004210
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Chien W., et al. (2000) J Biol Chem. 275(25):19422-7.
Tariq Hamid., et al. (2005) Molecular Cancer. 4(1):3.

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