RAP1A, 1-181aa, Human

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01-1858-1A
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Proteins, Recombinant
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Product Name RAP1A, 1-181aa, Human
Background Ras-related protein Rap-1A (RAP1A) belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. This Protein Induces morphological reversion of a cell line transformed by a Ras oncogene and Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Recombinant human RAP1A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Synonyms KREV1, G-22K, C21KG, Ras-related protein Rap-1A, G 22K, GTP binding protein smg p21A, KREV 1, OTTHUMP00000013741, RAP 1A, RAP1, RAP1A member of RAS oncogene family, Ras related protein Krev 1, Ras related protein Rap 1A, RAS related protein RAP1A, SMGP21
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDCQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTEDVP MILVGNKCDL EDERVVGKEQ GQNLARQWCN CAFLESSAKS KINVNEIFYD LVRQINRKTP VEKKKPKKKS C
Molecular Weight 14.8 kDa(138aa), confirmed by MALDI-TOF
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol
Purity > 85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_001010935
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Han, L., et al. (1995) Mol Cell Biol. 15 (3): 1318-23.
Rebhun, J F, et al. (2000) J Biol Chem. 275 (45): 34901-8.

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