RBBP9, 1-186aa, Human

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01-P1311
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Proteins, Recombinant
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Product Name RBBP9, 1-186aa, Human
Background Retinoblastoma binding protein, also known as RBBP9, localizes to both the nucleus and the cytoplasm. RBBP9 is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Specifically, RBBP9 interacts with retinoblastoma(Rb) and provides cellular resistance to the growth-inhibitory effects of TGFbeta1, thus facilitating the cellular transformation process. Recombinant human RBBP9 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms Retinoblastoma binding protein 9, BOG, RBBP10
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MASPSKAVIV PGNGGGDVTT HGWYGWVKKE LEKIPGFQCL AKNMPDPITA RESIWLPFME TELHCDEKTI IIGHSSGAIA AMRYAETHRV YAIVLVSAYT SDLGDENERA SGYFTRPWQW EKIKANCPYI VQFGSTDDPF LPWKEQQEVA DRLETKLHKF TDCGHFQNTE FHELITVVKS LLKVPA
Molecular Weight 26.6 kDa (240aa), confirmed by MALDI-TOF
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.1M NaCl
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_006597
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Woitach J T., et al. (1998) Nat Genet. 19:371-374.
Woitach J T., et al. (1999) Cytogenet Cell Genet. 85:252-253.

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