RRM2, 1-389aa, Human

Catalog
01-1847-2
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Proteins, Recombinant
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Product Name RRM2, 1-389aa, Human
Background RRM2, also known as ribonucleotide reductase M2, is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. This protein plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. Recombinant human RRM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques
Synonyms R2, RR2, RR2M, Ribonucleoside-diphosphate reductase subunit M2 Ribonucleotide reductase M2 subunit, Ribonucleotide reductase small subunit,
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN FFEKRVGEYQ RMGVMSSPTE NSFTLDADF
Molecular Weight 37.8 kDa (348aa) confirmed by MALDI-TOF
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol
Purity > 85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_001025
Host E.coli
Tag T7 tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Torrents E, et al. (2002) J Mol Evol. 55(2):138-52
Herrick J,et al. (2007) Mol Microbiol. 63(1):22-34

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