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|Product Name||RUNX3, 53-186aa, Human|
|Background||RUNX3, also known as runt-related transcription factor 3, belongs to the RUNX family that regulate the expression of genes involved in cellular differentiation and cell cycle progression. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It is a strong candidate as a gastric cancer tumor suppressor. Recombinant human RUNX3, fused to His-tag at N-terminus, protein was expressed in E.coli and purified by using conventional chromatography techniques|
|Synonyms||AML2, CBFA3, PEBP2aC, Runt-related transcription factor 3 Acute myeloid leukemia 2 protein, Acute myeloid leukemia gene 2, AML 2, CBF alpha 3, CBFA 3, Core binding factor alpha 3 subunit, core binding factor, Core binding factor runt domain alpha subunit 3, Core binding factor subunit alpha 3.M574, core-binding factor, FLJ34510, MGC16070, Oncogene AML 2, PEA2 alpha C, PEBP2 alpha C, Pebp2a3, Polyomavirus enhancer binding protein 2 alpha C subunit, runt domain alpha subunit 3, runt related transcription factor 3, RUNX 3, SL3 3 enhancer factor 1 alpha C subunit, SL3/AKV core binding factor alpha C subunit, Transcription factor AML2.|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MRSMVDVLAD HAGELVRTDS PNFLCSVLPS HWRCNKTLPV AFKVVALGDV PDGTVVTVMA GNDENYSAEL RNASAVMKNQ VARFNDLRFV GRSGRGKSFT LTITVFTNPT QVATYHRAIK VTVDGPREPR RHRQK|
|Molecular Weight||19.5 kDa (172aa), confirmed by MALDI-TOF|
|Concentration||0.5mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_004341|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Vogiatzi P. et al. (2006) Cancer Biol Ther. 5(4):371-4.
Li QL,et al. (2002)Cell. 109(1):113-24.
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