S100A8, 1- 93aa, Human, Recombinant

Catalog
01-2081A8
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Proteins, Recombinant
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Product Name S100A8, 1- 93aa, Human, Recombinant
Background S100 calcium binding protein A8, also known as MRP8, is a member of the S100 family, EF-hand superfamily of Calcium binding proteins. S100A8 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Altered expression of this protein is associated with the disease cystic fibrosis. Recombinant human S100A8 was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms Calgranulin-A, MRP-8, CFAG, CAGA, S100 calcium binding protein A8 60B8Ag, AI323541, B8Ag, BEE11, CAGA, Calprotectin L1L subunit, Calprotectin, included, CGLA, Chemotactic cytokine CP-10, CP-10, Cystic fibrosisantigen, L1Ag, Leukocyte L1 complex light chain, MA387, MIF, Migration inhibitory factor-related protein 8, Myeloid-related protein 8, Neutrophil cytosolic 7 kDa protein, NIF, p8, Pro-inflammatory S100 cytokine, Protein S100-A8, S100 calcium binding protein A8 (calgranulin A), S100A8, S100A8/S100A9 complex, included, Urinary stone protein band A.
Species Human
Amino Acid Sequence MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE
Molecular Weight 27.9 kDa (268aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Purity > 90% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_002955
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Kerkhoff C., et al. (1999) Biochim. Biophys. 1448(2):200-11.
Nacken W., et al. (2003) Biochim. Biophys. 60(6):569-80.

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