Serum amyloid A, 19-122aa, Human, Recombinant

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01-2241
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Proteins, Recombinant
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Product Name Serum amyloid A, 19-122aa, Human, Recombinant
Background Serum amyloid A1(SAA1) protein is made primarily in the liver and circulates in low levels in the blood. This protein appears to play a role in the immune system. Levels of this protein increase in the blood and other tissues under conditions of inflammation. SAA1 may help repair damaged tissues, acts as an antibacterial agent, and signal the migration of germ-fighting cells to sites of infection. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis. Recombinant Serum amyloid A protein was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms SAA1, PIG4, TP53I4, Amyloid fibril protein AA, Amyloid protein A, MGC111216, SAA, SAA2, Serum amyloid A protein precursor, Serum amyloid A1 isoform 1, Serum amyloid A1 isoform 2, Tumor protein p53 inducible protein 4.
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGP GGVWAAEAIS DARENIQRFF GHGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY
Molecular Weight 38.7 kDa (351aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1mM DTT.
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # AAI_05797
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Betts JC., et al. (1991) Scand J Immunol. 34(4):471-82.
Yilmaz E., et al. (2003) Turk J Pediatr. 45(3):198-202.

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