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|Product Name||SHH, 24-197aa, Human|
|Background||SHH, also known as Sonic hedgehog protein, is one of three proteins in the mammalian signaling pathway family called hedgehog. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. It controls cell division of adult stem cells and has been implicated in development of some cancers. Recombinant human SHH protein, fused to His-tag at C-terminus was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||HHG1, HLP3, HPE3, SMMCI, TPT, TPTPS, Sonic hedgehog protein HHG 1, HLP 3, Holoprosencephaly 3, HPE 3, MCOPCB5, SHH, SMMC I, SMMCI, Sonic Hedgehog (Drosophila) homolog, sonic hedgehog homolog (Drosophila), Sonic hedgehog homolog,|
|Amino Acid Sequence||MCGPGRGFGK RRHPKKLTPL AYKQFIPNVA EKTLGASGRY EGKISRNSER FKELTPNYNP DIIFKDEENT GADRLMTQRC KDKLNALAIS VMNQWPGVKL RVTEGWDEDG HHSEESLHYE GRAVDITTSD RDRSKYGMLA RLAVEAGFDW VYYESKAHIH CSVKAENSVA AKSGGLEHHH HHH|
|Molecular Weight||55.7 kDa (508aa), confirmed by MALDI-TOF|
|Concentration||0.5mg/ml (determined by Bradford assay)|
|Form||Liquid, in Phosphate Buffered Saline pH7.4 containing 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_000184|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Marigo V, et al. (1996) Proc Natl Acad Sci U S A. 93(18):9346-51
Kolpak A, et al. (2005) J Neurosci. 25(13):3432-41
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