| Product Name | STRADA, 1-314aa, Human |
|---|---|
| Description | STE20-related kinase adapter protein alpha isoform 5, also known as STRADA, is a member of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRADA-LKB1 interaction results in phosphorylation of STRADA and enhanced autophosphorylation of LKB1. Recombinant human STRADA protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Synonyms | STE20-related kinase adapter protein alpha isoform 5, LYK5, NY-BR-96, PMSE, Stlk, STRAD |
| Host | E.coli |
| Molecular Weight | 36.8 kDa (332aa) |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMSFLVSK PERIRTNDAS SESIASFSKQ EVMSSFLPEG GCYELLTVIG KGFEDLMTVN LARYKPTGEY VTVRRINLEA CSNEMVTFLQ GELHVSKLFN HPNIVPYRAT FIADNELWVV TSFMAYGSAK DLICTHFMDG MNELAIAYIL QGVLKALDYI HHMGYVHRSV KASHILISVD GKVYLSGLRS NLSMISHGQR QRVVHDFPKY SVKVLPWLSP EVLQQNLQGY DAKSDIYSVG ITACELANGH VPFKDMPATQ MLLEKLNGTV PCLLDTSTIP AEELTMSPSR SVANSGLSDS LTTSTPRPSN GPVPAPS |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| Purity | > 85% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| References |
Avizienyte E., et al. (1998) Cancer Res. 58: 2087-2090. Baas A F., et al. (2003) EMBO J. 22: 3062-3072. |
| Supplier | ARP |
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