STYX, 1-223aa, Human

Catalog
01-P1443
$0.00
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Proteins, Recombinant
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More Information
Product Name STYX, 1-223aa, Human
Background STYX, also known as serine/threonine/tyrosine-interacting protein, belongs to the protein-tyrosine phosphatase family. It contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. It seems to play a role in spermiogenesis. Recombinant human STYX protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Synonyms Serine/threonine/tyrosine-interacting protein, FLJ42934
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSHMEDVKL EFPSLPQCKE DAEEWTYPMR REMQEILPGL FLGPYSSAMK SKLPVLQKHG ITHIICIRQN IEANFIKPNF QQLFRYLVLD IADNPVENII RFFPMTKEFI DGSLQMGGKV LVHGNAGISR SAAFVIAYIM ETFGMKYRDA FAYVQERRFC INPNAGFVHQ LQEYEAIYLA KLTIQMMSPL QIERSLSVHS GTTGSLKRTH EEEDDFGTMQ VATAQNG
Molecular Weight 46.9kDa (410aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
Concentration 1mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 200mM NaCl
Purity > 85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_660294
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Wishart MJ. et al. (1995) J. Biol. Chem. 270:26782-26785.
Wishart MJ. et al. (2002) Proc Natl Acad Sci U S A. 99:2112-2117.

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