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|Product Name||SYCE3, 1-88aa, Human|
|Background||SYCE3(synaptonemal complex central element protein 3) is major component of the transverse central element of synaptonemal complexes (SCS). The synaptonemal complex is a protein structure that forms between homologous chromosomes (two pairs of sister chromatids) during meiosis and that is thought to mediate chromosome pairing, synapsis, and recombination (crossing-over). This protein required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Recombinant human SYCE3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||synaptonemal complex central element protein 3, testis highly expressed protein 2, C22orf41, chromosome 22 open reading frame 41, THEG-2, THEG2, SYCE-3|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MDDADPEERN YDNMLKMLSD LNKDLEKLLE EMEKISVQAT WMAYDMVVMR TNPTLAESMR RLEDAFVNCK EEMEKNWQEL LHETKQRL|
|Molecular Weight||34.7 kDa (300aa), confirmed by MALDI-TOF|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 40% glycerol,1mM DTT|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_001116697|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Schramm S, et al. (2011) PLoS Genet, May;7(5):e1002088|
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