TIRAP, 1-221aa, Human

Catalog
01-P1675
$0.00
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Proteins, Recombinant
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Product Name TIRAP, 1-221aa, Human
Background TIRAP (toll-interleukin1 receptor (TIR) domain containing adaptor protein) contains 1 TIR domain. This protein is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Adapter protein, TIRAP, is involved in TLR2 and TLR4 signaling pathways in the innate immune response. Recombinant human TIRAP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms toll-interleukin1 receptor (TIR) domain containing adaptor protein, BACTS1, Mal, wyatt
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMASSTSL PAPGSRPKKP LGKMADWFRQ TLLKKPKKRP NSPESTSSDA SQPTSQDSPL PPSLSSVTSP SLPPTHASDS GSSRWSKDYD VCVCHSEEDL VAAQDLVSYL EGSTASLRCF LQLRDATPGG AIVSELCQAL SSSHCRVLLI TPGFLQDPWC KYQMLQALTE APGAEGCTIP LLSGLSRAAY PPELRFMYYV DGRGPDGGFR QVKEAVMRYL QTLS
Molecular Weight 28.4 kDa (253aa), confirmed by MALDI-TOF
Concentration 0.25 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 40% glycerol,1mM DTT
Purity > 90% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_001034750
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Semaan N., et al. (2008) J. Immunol. 180:3485-3491
Nagpal K., et al. (2009) J. Biol. Chem. 284:25742-25748

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