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|Product Name||TNFRSF14, 39-202aa, Human|
|Background||TNFRSF14, as known as herpesvirus entry mediator (HVEM), is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Recombinant human TNFRSF14 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Synonyms||ATAR, CD270, HVEA, HVEM, LIGHTR, TR2|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSLPSCKED EYPVGSECCP KCSPGYRVKE ACGELTGTVC EPCPPGTYIA HLNGLSKCLQ CQMCDPAMGL
RASRNCSRTE NAVCGCSPGH FCIVQDGDHC AACRAYATSS PGQRVQKGGT ESQDTLCQNC PPGTFSPNGT LEECQHQTKC SWLVTKAGAG
|Molecular Weight||21kDa (189aa), confirmed by MALDI-TOF|
|Concentration||0.25 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl (pH8.0) containing 30% glycerol,
0.15M NaCl, 1mM DTT
|Purity||> 85% by SDS-PAGE|
|NCBI Accession #||NP_003811|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Montgomery RI. et al. (1996) Cell. 87:427-436.
Kwon BS. et al. (1997) J Biol Chem. 272:14272-14276.
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