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|Product Name||TSG101, 1-145aa, Human, Recombinant|
|Background||TSG101(Tumor susceptibility gene 101) protein belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. This protein contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. Mutations and alternative splicing in this protein occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. Recombinant human TSG101 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||TSG10, VPS23, Tumor susceptibility gene 101 ESCRT I complex subunit TSG101, TSG 10, TSG 101, Tumor susceptibility gene 10, Tumor susceptibility gene 101, Tumor susceptibility protein, Tumor susceptibility protein isoform 3, VPS 23, VPS23.|
|Amino Acid Sequence||MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAVS ESQLKKMVSK YKYRDLTVRE TVNVITLYKD LKPVLDSYVF NDGSSRELMN LTGTIPVPYR GNTYNIPICL WLLDTYPYNP PICFVKPTSS MTIKTGKHVD ANGKIYLPYL HEWKHPQSDL LGLIQVMIVV FGDEPPVFSR P|
|Molecular Weight||22.9 kDa (198aa), confirmed by MALDI-TOF|
|Concentration||1 mg/ml (determined by BCA assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_006283|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Vardhana S., et al. (2010) Immunity. 32(4):531-40.
Popov S., et al. (2009) J Virol. 83(14):7185-93.
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