UBE2L6, 1-152aa, Human, Recombinant

Category: Proteins
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01-2014-L6
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Product Name UBE2L6, 1-152aa, Human, Recombinant
Description Ubiquitin-conjugating enzyme E2L6 (UBE2L6), also known as UbcH8, is a member of the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination of a protein substrate requires the concerted action of 3 classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin protein ligases. The E2 ubiquitin-conjugating enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Recombinant human UBE2L6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms UBCH8, RIG-B, Ubiquitin conjugating enzyme E2L 6, UBE2L6, Ubiquitin conjugating enzyme E2L 6 MGC40331, Retinoic acid induced gene B protein, RIG B, UBCH 8, Ubiquitin carrier protein, Ubiquitin carrier protein L6, Ubiquitin protein ligase, Ubiquitin protein ligase L6, Ubiquitin/ISG15 conjugating enzyme E2 L6.
Host E.coli
Molecular Weight 11.7 kDa (105 aa), confirmed by MALDI-TOF.
Amino Acid Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASM RVVKELEDLQ KKPPPYLRNL SSDDANVLVW HALLLPDQPP YHLKAFNLRI SFPPEYPFKP PMIKFTTKIY HPNVDENGQI CLPIISSENW KPCTKTCQVL EALNVLVNRP NIREPLRMDL ADLLTQNPEL FRKNAEEFTL RFGVDRPS
Tag His-tag
Reactivity Human
Applications SDS-PAGE
Form Liquid, in Phosphate buffer saline (PBS) , pH 7.4
Concentration 1 mg/ml (determined by Bradford assay)
Purity > 90% by SDS PAGE
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
References Ardley HC., et al. (2000) Cytogenet Cell Genet. 89(1-2):137-140.
Movnihan TP., et al. (1999) J Biol Chem. 274(43):30963-30968.
Supplier ARP

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