UBE2R2, 1-238aa, Human

Catalog
01-P2374
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Proteins, Recombinant
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Product Name UBE2R2, 1-238aa, Human
Background UBE2R2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This protein is a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. Recombinant human UBE2R2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms CDC34B, E2-CDC34B, UBC3B
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMAQQQMT SSQKALMLEL KSLQEEPVEG FRITLVDESD LYNWEVAIFG PPNTLYEGGY FKAHIKFPID
YPYSPPTFRF LTKMWHPNIY ENGDVCISIL HPPVDDPQSG ELPSERWNPT QNVRTILLSV ISLLNEPNTF SPANVDASVM FRKWRDSKGK
DKEYAEIIRK QVSATKAEAE KDGVKVPTTL AEYCIKTKVP SNDNSSDLLY DDLYDDDIDD EDEEEEDADC YDDDDSGNEE S
Molecular Weight 9.3 kDa (82aa) confirmed by MALDI-TOF
Concentration 0.25 mg/ml (determined by BCA assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol
Purity >85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_060281
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Yoshida,T., et al. (2010) Int. J. Mol. Med. 25 (4), 649-656
Oguri,M., et al. (2006) Am. J. Hypertens. 23 (1), 70-77

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