WWOX, 1-234aa, Human, Recombinant

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01-2090
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Proteins, Recombinant
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Product Name WWOX, 1-234aa, Human, Recombinant
Background WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death. Recombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Synonyms WW domain containing oxidoreductase, D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1, WW domain containing oxidoreductase 5330426P09Rik, 9030416C10Rik, EC 1.1.1.- Fragile site FRA16D Oxireductase, MGC55975, PRO0128, Putative oxidoreductase, zgc:55975, Short chain dehydrogenase/reductase family 41C, member 1, WW domain-containing protein WWOX.
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG
Molecular Weight 29.2 kDa (260aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50mM NaCl, 10% glycerol
Purity > 85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # AAH03184
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Bouteille N., et al. (2009), Oncogene. 28(28):2569-80.
Gourley C., et al. (2009). Cancer Res. 69(11):4835-42.

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