| Product Name | WWOX, 1-234aa, Human, Recombinant |
|---|---|
| Description | WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death. Recombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
| Synonyms | WW domain containing oxidoreductase, D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1, WW domain containing oxidoreductase 5330426P09Rik, 9030416C10Rik, EC 1.1.1.- Fragile site FRA16D Oxireductase, MGC55975, PRO0128, Putative oxidoreductase, zgc:55975, Short chain dehydrogenase/reductase family 41C, member 1, WW domain-containing protein WWOX. |
| Host | E.coli |
| Molecular Weight | 29.2 kDa (260aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50mM NaCl, 10% glycerol |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 85% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| References |
Bouteille N., et al. (2009), Oncogene. 28(28):2569-80. Gourley C., et al. (2009). Cancer Res. 69(11):4835-42. |
| Supplier | ARP |
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