Product Name | Anti-CD264 / TRAIL-R4 Monoclonal Antibody |
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Description | TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4). The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension.The content of a vial (0.4 ml) is sufficient for 100 tests. |
Clone | TRAIL-R4-01 |
Immunogen | TRAIL-R4 (aa 1-210) - hIgGhc fusion protein |
Isotype | IgG1 |
Specificity | The antibody TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells. |
Reactivity | Human |
Applications | FC |
Form | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide. |
Storage | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
Supplier | Exbio |
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