| Product Name | Anti-CD144 / VE-cadherin Monoclonal Antibody |
|---|---|
| Description | CD144 / VE-cadherin (cadherin 5) is the major cadherin that is present at endothelial junctions. It is also strictly endothelial specific. Under vascular permeability increasing conditions (and also in capillaries and veins) CD144 is being phosphorylated, which promotes its rapid and reversible internalization. On the contrary, binding of p120 catenin (delta1 catenin) maintains CD144 localization at the plasma membrane, which stabilizes the junction and reduces vascular permeability. |
| Clone | 55-7H1 |
| Immunogen | Human endothelial cells |
| Isotype | IgG1 |
| Specificity | The mouse monoclonal antibody 55-7H1 recognizes a calcium-independent epitope on CD144 (VE-cadherin, cadherin 5), an adhesion molecule expressed on endothelial cells. |
| Reactivity | Human |
| Applications | FC, ICC, IHC, IP, WB |
| Form | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage | Store at 2-8°C. Do not freeze. |
| Supplier | Exbio |
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