| Product Name | SUR1 Antibody: ATTO 594 |
|---|---|
| Description | Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2). Mouse Anti-Rat SUR1 Monoclonal IgG1 |
| Synonyms | AM60008PU-N Antibody, ABC36 Antibody, Abcc8 Antibody, ATP binding cassette sub family C member 8 Antibody, HHF1 Antibody, HRINS Antibody, MRP8 Antibody, PHHI Antibody, SUR Antibody, SUR1 Antibody, Sulfonylurea receptor (hyperinsulinemia) Antibody, ATP bin |
| Host | Mouse |
| Clone | S289-16 |
| Immunogen | Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1 |
| Isotype | IgG1 |
| Specificity | Detects ~160kDa. Does not cross-react with SUR2B. |
| Reactivity | Hamster, Human, Mouse, Rat |
| Applications | ICC, IF, IHC, WB |
| Form | Purified, in PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Gene Id | NP_037171.2. 25559 |
| Uniprot | Q09429 |
| Supplier | Stressmarq Biosciences |
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