Synaptotagmin-6 Antibody: PE/ATTO 594

Category: Antibodies
Catalog
SMC-425D-P594
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Product Name Synaptotagmin-6 Antibody: PE/ATTO 594
Description Synaptotagmins constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins. The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacylbackbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Mouse Anti-Mouse Synaptotagmin-6 Monoclonal IgG1
Synonyms SYT-6 Antibody, SYT6 Antibody, Synaptotagmin 6 Antibody, Synaptotagmin VI Antibody, SytVI Antibody, Syt VI Antibody, Synaptotagmin6 Antibody, SynaptotagminVI Antibody
Host Mouse
Clone S270-47
Immunogen Fusion protein amino acids 246-333 (Cytoplasmic C2A domain) of mouse Synaptotagmin-6
Isotype IgG1
Specificity Detects ~55kDa. Does not cross-react with other synaptotagmins.
Reactivity Human, Mouse, Rat
Applications ICC, IF, WB
Form Purified, in PBS pH7.4, 50% glycerol, 0.09% sodium azide
Gene Id NP_061270.2. 54524
Uniprot Q9R0N8
Supplier Stressmarq Biosciences

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