TSG101, 1-145aa, Human, Recombinant

Proteins, Recombinant
More Information
Product Name TSG101, 1-145aa, Human, Recombinant
Applications SDS-PAGE
Background TSG101(Tumor susceptibility gene 101) protein belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. This protein contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. Mutations and alternative splicing in this protein occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. Recombinant human TSG101 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 1 mg/ml (determined by BCA assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 22.9 kDa (198aa), confirmed by MALDI-TOF
NCBI Accession # NP_006283
Purity > 90% by SDS-PAGE
References Vardhana S., et al. (2010) Immunity. 32(4):531-40.
Popov S., et al. (2009) J Virol. 83(14):7185-93.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms TSG10, VPS23, Tumor susceptibility gene 101 ESCRT I complex subunit TSG101, TSG 10, TSG 101, Tumor susceptibility gene 10, Tumor susceptibility gene 101, Tumor susceptibility protein, Tumor susceptibility protein isoform 3, VPS 23, VPS23.
Tag His-tag

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