| Product Name | Tsp23 Antibody: Alkaline Phosphatase |
|---|---|
| Description | p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate–mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology. Specifically TSP23 (transcript similar p23) displays 44% and 17% amino acid identity with p23 and Sba1p respectively (10). Mouse Anti-Human Tsp23 Monoclonal IgG1 Kappa |
| Synonyms | Transcript similar p23 Antibody, AARSD1 Antibody, AASD1_HUMAN Antibody, Alanyl-tRNA editing protein Aarsd1 Antibody, Alanyl-tRNA synthetase domain containing 1 Antibody, Alanyl-tRNA synthetase domain-containing protein 1 Antibody, MGC2744 Antibody, OTTHUM |
| Host | Mouse |
| Clone | Tsp232A |
| Immunogen | Recombinant tsp23 |
| Isotype | IgG1 kappa |
| Specificity | Detects ~19kDa. Detects Tsp23, no cross-reactivity to p23. |
| Reactivity | Human, Mouse |
| Applications | AM, IHC, WB |
| Form | Purified, in PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Gene Id | NP_001136126.1. 80755 |
| Uniprot | B9A003 |
| Supplier | Stressmarq Biosciences |
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