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|Product Name||TSSK6, 1-273aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMSGDKLL SELGYKLGRT IGEGSYSKVK VATSKKYKGT VAIKVVDRRR APPDFVNKFL PRELSILRGV
RHPHIVHVFE FIEVCNGKLY IVMEAAATDL LQAVQRNGRI PGVQARDLFA QIAGAVRYLH DHHLVHRDLK CENVLLSPDE RRVKLTDFGF
GRQAHGYPDL STTYCGSAAY ASPEVLLGIP YDPKKYDVWS MGVVLYVMVT GCMPFDDSDI AGLPRRQKRG VLYPEGLELS ERCKALIAEL
LQFSPSARPS AGQVARNCWL RAGDSG
|Background||TSSK6, also known as testis-specific serine/threonine-protein kinase 6, is a member of the CAMK Ser/Thr protein kinase family. This protein contains one protein kinase domain. It is highly expressed in the testis and lowly expressed in the colon, prostate, thymus, small intestine, and peripheral blood leukocytes. It interacts with the heatshock proteins HSPA8, HSPCB, and HAPA1A; these interactions appear to be required for TSSK6 kinase activity. It plays a role in DNA condensation during postmeiotic chromatin remodeling. Otherwise, TSSK6 is required for sperm production and function. Recombinant human TSSK6 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT.|
|Intended Use||For Research Use Only|
|Molecular Weight||21.7 kDa (190aa) confirmed by MALDI-TOF|
|NCBI Accession #||NP_114426|
|Purity||> 80% by SDS-PAGE|
|References||Su D. et al. (2010) Asian J Androl. 12:234-239.
Sosnik J et al. (2009) J Cell Sci. 122:2741-2749.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Testis-specific serine kinase 6, CT72, FKSG82, SSTK, TSSK4|
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