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|Product Name||TTC11, 1-122aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MEAVLNELVS VEDLLKFEKK FQSEKAAGSV SKSTQFEYAW CLVRSKYNDD IRKGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT EPQNNQAKEL ERLIDKAMKK DG|
|Background||TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission. This protein can induce cytochrome C release from the mitochondrion to the cytosol, ultimately leading to apoptosis. It is also involved in peroxisomal growth and division. The C terminus is required for mitochondrial localisation, while the N teminus is necessary for mitochondrial fission. Recombinant human TTC11, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 1mM EDTA|
|Intended Use||For Research Use Only|
|Molecular Weight||28.1 kDa (249aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_057152|
|Purity||> 95% by SDS-PAGE|
|References||Martinou JC., et al. (2003) J Biol Chem. 278(38):36373-9.
Yoon Y., et al. (2008) Exp Cell Res. 314(19):3494-507
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||FIS1, Tetratricopeptide repeat domain 11 2010003O14Rik, CGI 135, CGI135, FIS 1, Fis1 homolog, FIS1, S, cerevisiae, homolog of, Fission 1 (mitochondrial outer membrane) homolog, Fission 1 (mitochondrial outer membrane) homolog (S, cerevisiae), Fission 1 (mitochondrial outer membrane) homolog (yeast) Fission 1 homolog, H NH0132A01.6, hFis 1, hFis1, Mitochondrial fission 1 protein, Tetratricopeptide repeat protein 11, TPR repeat protein 11, TTC 11.|
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