VPS24, 1-222aa, Human

Catalog
01-2177-24
$0.00
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Proteins, Recombinant
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More Information
Product Name VPS24, 1-222aa, Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGLFGKTQEK PPKELVNEWS LKIRKEMRVV DRQIRDIQRE EEKVKRSVKD AAKKGQKDVC IVLAKEMIRS RKAVSKLYAS KAHMNSVLMG MKNQLAVLRV AGSLQKSTEV MKAMQSLVKI PEIQATMREL SKEMMKAGII EEMLEDTFES MDDQEEMEEE AEMEIDRILF EITAGALGKA PSKVTDALPE PEPPGAMAAS EDEEEEEEAL EAMQSRLATL RS
Applications SDS-PAGE
Background VPS24, also known as Charged multivesicular body protein 3(CHMP3), belongs to the vacuolar sorting protein family and function as chromatin modifying proteins. It associates directly with CHMP2 and CHMP4 for the disassembly of ESCRT-III complex in an ATP-dependent manner. During HIV-1 infection, the virus uses the ESCRT-III complex to mediate budding and exocytosis of viral proteins. Overexpression of VPS24 strongly inhibits HIV-1 release. Recombinant human VPS24 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Concentration 0.5mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 100mM NaCl
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 26.1kDa (236aa), confirmed by MALDI-TOF
NCBI Accession # NP_057163
Purity > 90% by SDS-PAGE
References Muziol T. et al. (2006) Dev. Cell. 10: 821-830.
Bache K.G. et al. (2006) Mol. Biol. Cell 17: 2513-2523.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms Charged multivesicular body protein 3, CGI-149, CHMP3, FLJ38114, NEDF
Tag His-tag

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