| Product Name | 736-745-TAT |
|---|---|
| Description | 736-745-TAT, also known as TAT-TRPV1(736-745), is a cell permeable TRPV1 fragment that can inhibit the interaction of TRPV1 and AKAP79. 736-745-TAT consists of amino acids 736-749 from the TRPV1 C-terminal domain, combined with amino acids 47–57 of TAT to promote uptake across neuronal cell membranes. 736-745-TAT inhibits both the first and the second phase of pain behaviour in the formalin test, implying an effect on both acute and inflammatory pain. |
| Synonyms | TAT-TRPV1(736-745) |
| Molecular Weight | 2929.41 Da |
| Target | Protein-protein interactions,Transient receptor potential (TRP) channels |
| Amino Acid Sequence | KDDYRWCFRVYGRKKRRQRRR |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Fischer et al (2013) Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia. J. Neurosci. 33(17) 7407 PMID: 23616546 Related productsAll protein-protein interaction modulators >All transient receptor potential (TRP) channel modulators >All pain research products >All cell penetrating peptides > |
| Supplier | Isca Biochemicals Limited |
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