Cytokines Chemokines

CATEGORY

Cytokine Product Focus

Cytokines were first identified in the 1940’s as being soluble factors produced by white blood cells [1].  It is now appreciated that cytokines can be produced by most cell types and can have multiple functions.  This makes understanding the complex network of cells and cytokines in normal and disease states a challenge.

Most cytokines are small, non-structural, secreted peptides, proteins or glycoproteins which function by binding to cell surface receptors. These include interleukins (IL), chemokines, interferons (IFN), colony stimulating factors (CSF) and transforming growth factors (TGF).  Some, like members of the TNF superfamily, function as type II transmembrane proteins which can be released from the membrane as soluble factors.

Due to their important role, particularly in immunology and inflammation, some cytokines have become important drug targets [2].

American Research Products supply a wide variety of cytokines, a selection of which are shown here with some of their cellular sources. Also available are anti-cytokine antibodies, anti-cytokine receptor antibodies and cytokine assay kits.

References

[1] Dinarello CA. Historical insights into cytokines. Eur J Immunol. 2007 Nov;37 Suppl 1:S34-45.

[2] Szollosi, DE et al.  Current and novel anti‐inflammatory drug targets for inhibition of cytokines and leucocyte recruitment in rheumatic diseases.Vol 70, Issue 1, Jan 2018, p18-26  https://doi.org/10.1111/jphp.12811

Items 1-10 of 391

Page
per page
Set Descending Direction
  1. Anti-BAFF Monoclonal Antibody
    28-60070M
    Sandwich ELISA, Western Blot
    Human
    From $159.00
  2. Anti-BAFF Polyclonal Antibody
    28-60070P
    ELISA, WB
    Human
    From $199.00
  3. Anti-BAFF Polyclonal Antibody
    10-P9567
    WB
    Mouse, Rat, Reacts with: human
    From $289.00
  4. Anti-BAFF Polyclonal Antibody
    10-P1541
    IHC, WB
    Mouse, Predicted to work with: rat, Reacts with: h......
    From $319.00
  5. Anti-BAFF Polyclonal Antibody, Biotin Conjugate
    28-60070BT
    ELISA, WB
    Human
    From $199.00
  6. Anti-BAFF Receptor Polyclonal Antibody
    10-P1391
    WB
    Reacts with: human
    From $289.00
  7. Anti-CCL18 Polyclonal Antibody
    10-P9023
    ELISA, WB
    Reacts with: human
    From $289.00
  8. Anti-CCL3 Polyclonal Antibody
    10-P9571
    ELISA, WB
    Reacts with: human
    From $289.00
  9. Anti-CCL3 Polyclonal Antibody
    10-P9022
    ELISA, WB
    Reacts with: rat
    From $289.00
  10. Anti-CCL4 Polyclonal Antibody
    10-P9572
    ELISA, WB
    Reacts with: human
    From $289.00

Items 1-10 of 391

Page
per page
Set Descending Direction

Have questions?

An ARP Customer Service Representative is happy to help!