| Product Name | A_40 Polyclonal Antibody |
|---|---|
| Description | A_ derives from APP via proteolytic cleavage by proteases called _-, _- and _-secretase. The _-secretase cleavage precludes the formation of A_, while the _- and _-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). This antibody can recogniaze the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta. |
| Synonyms | A4, AAA, ABETA, ABPP, AICD 50, AICD 57, AICD 59, Amyloid beta A4 protein, APP, beta Amyloid, CTFgamma, CVAP, Protease nexin II, S APP alpha Soluble APP beta |
| Host | Rabbit |
| Immunogen | Recombinant Human Beta-amyloid 40 protein |
| Isotype | IgG |
| Reactivity | Mouse, Rat |
| Applications | IHC |
| Form | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | P05067 |
| Background | A_ derives from APP via proteolytic cleavage by proteases called _-, _- and _-secretase. The _-secretase cleavage precludes the formation of A_, while the _- and _-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). This antibody can recogniaze the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta. |
| Supplier | Elabscience |
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