| Product Name | Acrolein Antibody: ATTO 594 |
|---|---|
| Description | Lipid peroxidation occurs when oxidizing agents attack carbon-carbon double bonds found in unsaturated lipids. In addition to membrane degradation, oxidation end-products have been found to damage cell viability through their mutagenic and toxic properties. These downstream functional consequences facilitate the development of disease and premature aging. Acrolein is an electrophilic conjugated aldehyde that is a terminal product of lipid peroxidation. Acrolein is highly mutagenic and reacts with nucleophilic functional groups in DNA and proteins such as cysteine, histidine, and lysine residues (1). Mouse Anti-Acrolein conjugated protein Monoclonal IgG1 |
| Synonyms | Acrolein modified protein Antibody, Acrolein conjugated protein Antibody, 2-Propen-1-one Antibody, 2-propenal Antibody, Acraldehyde Antibody, Acrolein Antibody, Acrylic aldehyde Antibody, Protein-bound Acrolein Antibody |
| Host | Mouse |
| Clone | 2H2 |
| Immunogen | Synthetic Acrolein modified Keyhole Limpet Hemocyanin (KLH). |
| Isotype | IgG1 |
| Specificity | Specific for Acrolein modified proteins. Does not detect free acrolein. Does not cross-react with Crotonaldehyde, Hexanoyl Lysine, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, Malondialdehyde, or Methylglyoxal modified proteins. |
| Applications | ELISA, FACS, FCM, ICC, IF, WB |
| Form | Purified, in PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide |
| Background | Lipid peroxidation occurs when oxidizing agents attack carbon-carbon double bonds found in unsaturated lipids. In addition to membrane degradation, oxidation end-products have been found to damage cell viability through their mutagenic and toxic properties. These downstream functional consequences facilitate the development of disease and premature aging. Acrolein is an electrophilic conjugated aldehyde that is a terminal product of lipid peroxidation. Acrolein is highly mutagenic and reacts with nucleophilic functional groups in DNA and proteins such as cysteine, histidine, and lysine residues (1). |
| Supplier | Stressmarq Biosciences |
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