| Product Name | ACTL6B Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ACTL6B |
| Synonyms | 53 kDa BRG1 associated factor B antibody; 53 kDa BRG1-associated factor B antibody; ACL 6B antibody; ACL6B antibody; ACL6B_HUMAN antibody; Actin like 6 antibody; Actin like protein 6B antibody; Actin like protein6B antibody; Actin related protein antibody; Actin related protein Baf53b antibody; actin-like 6B antibody; Actin-like protein 6B antibody; Actin-related protein Baf53b antibody; Actl 6 antibody; ACTL 6B antibody; Actl6 antibody; ACTL6 B antibody; Actl6b antibody; Arp Na antibody; ArpN a antibody; ArpN alpha antibody; ArpNa antibody; ArpNalpha antibody; Baf 53b antibody; BAF53B antibody; BRG1-associated factor 53B antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Actin-like protein 6B protein (1-280AA) |
| Isotype | IgG |
| Target | ACTL6B |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | O94805 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth . |
| Supplier | Cusabio |
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