| Product Name | ADPRHL2, 1-363aa, Human |
|---|---|
| Description | ADP-ribosylhydrolase like 2, also known as ADPRHL2, is a member of the ADP-ribosylglycohydrolase family. Expressed ubiquitously, ADPRHL2 uses magnesium as a cofactor to catalyze the hydrolysis of poly (ADP-ribose) that is synthesized after DNA damage. Also, ADPRHL2 plays an important role in the maintenance of normal neuronal cell function. Recombinant human ADPRHL2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | ADP-ribosylhydrolase like 2, ARH3 |
| Host | E. coli |
| Molecular Weight | 47.3 kDa (420aa), confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMAAAAM AAAAGGGAGA ARSLSRFRGC LAGALLGDCV GSFYEAHDTV DLTSVLRHVQ SLEPDPGTPG SERTEALYYT DDTAMARALV QSLLAKEAFD EVDMAHRFAQ EYKKDPDRGY GAGVVTVFKK LLNPKCRDVF EPARAQFNGK GSYGNGGAMR VAGISLAYSS VQDVQKFARL SAQLTHASSL GYNGAILQAL AVHLALQGES SSEHFLKQLL GHMEDLEGDA QSVLDARELG MEERPYSSRL KKIGELLDQA SVTREEVVSE LGNGIAAFES VPTAIYCFLR CMEPDPEIPS AFNSLQRTLI YSISLGGDTD TIATMAGAIA GAYYGMDQVP ESWQQSCEGY EETDILAQSL HRVFQKS |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.1M NaCl |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Kernstock S., et al. (2006) Sect F Struct Biol Cryst Commun. 62: 224-227 Mueller Dieckmann C., et al. (2006) Proc Natl Acad Sci USA. 103: 15026-15031. |
| Background | ADP-ribosylhydrolase like 2, also known as ADPRHL2, is a member of the ADP-ribosylglycohydrolase family. Expressed ubiquitously, ADPRHL2 uses magnesium as a cofactor to catalyze the hydrolysis of poly (ADP-ribose) that is synthesized after DNA damage. Also, ADPRHL2 plays an important role in the maintenance of normal neuronal cell function. Recombinant human ADPRHL2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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