| Product Name | ADRM1 Monoclonal Antibody |
|---|---|
| Description | The 26S proteasome is a key component of the ubiquitin-proteasome system,a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme,UCH37,and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts. |
| Synonyms | adhesion regulating molecule 1,ADRM1,ARM 1,ARM1,GP110,hRpn13,Rpn13,Rpn13 homolog |
| Host | Mouse |
| Clone | 1A1A3 |
| Immunogen | Fusion Protein of ADRM1 |
| Isotype | IgG3 |
| Reactivity | Human |
| Applications | ELISA, WB |
| Form | PBS with 0.1% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q16186 |
| Background | The 26S proteasome is a key component of the ubiquitin-proteasome system,a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme,UCH37,and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts. |
| Supplier | Elabscience |
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