| Product Name | AEC5 |
|---|---|
| Description |
AEC5 is a trimeric lipopeptoid with potent antifungal activity against Cryptococcus neoformans and Cryptococcus gattii and modest efficacy against other microbial pathogens. AEC5 rapidly reduces fungal burden in infected macrophages against C. neoformans, with nearly 50% reduction in fungal growth after 30 minutes and complete elimination of viable fungi within 3 hours. In mouse models AEC5 has an in vivo half-life of >20 hours and no observable toxicity following 28 days of daily injections. |
| Synonyms | AEC5, PT-109, antifungal, lipopeptoid, peptoid |
| Molecular Weight | 521.7 Da |
| Target | Antifungals |
| Amino Acid Sequence | Ntri-NLys-Nfur |
| Form | Freeze dried solid |
| Purity | 96.2% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: For more information about peptoids and their nomenclature please refer to the resources section |
| References |
Corson (2016) Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. ACS Med Chem Lett. 7(12) 1139 PMID: 27994753Spicer et al (2019) Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5. Biopolymers 110(6) e23276 PMID: 30938841 Related areas All peptoids >All antifungals > |
| Supplier | Isca Biochemicals Limited |
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