| Product Name | ALDOB Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ALDOB |
| Synonyms | ALDB antibody; ALDO B antibody; ALDO2 antibody; ALDOB antibody; ALDOB_HUMAN antibody; Aldolase 2 antibody; Aldolase B antibody; Aldolase B fructose bisphosphate antibody; Aldolase2 antibody; AldolaseB antibody; EC 4.1.2.13 antibody; Fructose bisphosphate aldolase B antibody; Fructose-bisphosphate aldolase B antibody; Liver type aldolase antibody; Liver-type aldolase antibody; MS1077 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human ALDOB. |
| Isotype | IgG |
| Target | ALDOB |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | P05062 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. Paolella G., Nucleic Acids Res. 12:7401-7410(1984). Sakakibara M., Nucleic Acids Res. 13:5055-5069(1985). Rottmann W.H., Proc. Natl. Acad. Sci. U.S.A. 81:2738-2742(1984). |
| Supplier | Cusabio |
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