| Product Name | alpha-MSH |
|---|---|
| Description |
alpha-MSH is an endogenous melanocortin receptor agonist with Ki values of 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively. alpha-MSH is primarily a pigmentary hormone of the vertebrates and reduces the concentration of proinflammatory mediators through the induction of cyclic adenosine monophosphate (cAMP), controlling inflammation in the brain and peripheral organs. alpha-MSH also possesses antimicrobial properties. |
| Synonyms | a-Melanotropin, a-N-acetyl-ACTH(1-13)-NH2, alpha-melanocyte-stimulating hormone |
| Molecular Weight | 1664.88 Da |
| Target | Antibacterials,Melanocortin receptors |
| Amino Acid Sequence | AcSYSMEHFRWGKPV-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 581-05-5 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N terminal acetyl, C terminal amide |
| References |
D'Agostino and Diano (2010) Alpha-melanocyte stimulating hormone: production and degradation. J Mol Med (Berl). 88(12) 1195 PMID: 20617297Singh and Mukhopadhyay (2014) Alpha-Melanocyte Stimulating Hormone: An Emerging Anti-Inflammatory Antimicrobial Peptide BioMed Research International Article ID 874610 PMID: 25140322Kravchychyn et al (2018) The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents. Ann Nutr Metab. 72 279 PMID: 29649791 Related areas All peptides >All melanocortin receptor modulators >All endocrinology research categories >All immunology research categories >All antimicrobial agents > |
| Supplier | Isca Biochemicals Limited |
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