| Product Name | alpha-Synuclein E46K, Human, Recomninant |
|---|---|
| Description | alpha-Synuclein E46K is a mutant form of alpha-synuclein which is changed at position 46 from glutamate(E) to lysine(K). Recent studies have shown that this mutant(E46K) of alpha-synuclein causes Parkinson and Lewy Body dementia(DLB). alpha-Synuclein E46K was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques |
| Synonyms | SNCA, NACP, PARK1, alpha-Synuclein, alpha synuclein E46k, alpha-synuclein e46k, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha, |
| Host | E. coli |
| Molecular Weight | 11.3 kDa (112 aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKKGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl |
| Concentration | 1 mg/ml (determined by BCA assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Juan J.Zarranz, . (2004) Ann. Neurol. 55, 164-173. |
| Background | alpha-Synuclein E46K is a mutant form of alpha-synuclein which is changed at position 46 from glutamate(E) to lysine(K). Recent studies have shown that this mutant(E46K) of alpha-synuclein causes Parkinson and Lewy Body dementia(DLB). alpha-Synuclein E46K was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques |
| Supplier | ARP |
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