| Product Name | ALPL Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ALPL |
| Synonyms | AKP2 antibody; Alkaline phosphatase liver/bone/kidney antibody; Alkaline phosphatase liver/bone/kidney isozyme antibody; Alkaline phosphatase tissue nonspecific isozyme antibody; Alkaline phosphatase, tissue-nonspecific isozyme antibody; Alkaline phosphomonoesterase antibody; Alpl antibody; AP TNAP antibody; AP-TNAP antibody; APTNAP antibody; BAP antibody; FLJ40094 antibody; FLJ93059 antibody; Glycerophosphatase antibody; HOPS antibody; Liver/bone/kidney type alkaline phosphatase antibody; MGC161443 antibody; MGC167935 antibody; PHOA antibody; PPBT_HUMAN antibody; Tissue non specific alkaline phosphatase antibody; Tissue nonspecific ALP antibody; TNAP antibody; TNSALP antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human ALPL |
| Isotype | IgG |
| Target | ALPL |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | P05186 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. |
| Supplier | Cusabio |
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