Amphiregulin Monoclonal Antibody

Category: Antibodies
Catalog
E-AB-27628
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Product Name Amphiregulin Monoclonal Antibody
Description Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor,pro-AREG. At the plasma membrane,pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment,AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form,28-,26-,16-kDa membrane anchored forms,and soluble 21-,19-,and 9-kDa forms .
Synonyms amphiregulin,AR,AREG,AREGB,CRDGF,SDGF
Host Mouse
Clone 1A1G9
Immunogen Fusion protein of Amphiregulin
Isotype IgG1
Reactivity Human, Rat
Applications ELISA, IHC, WB
Form PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Uniprot P15514
Background Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor,pro-AREG. At the plasma membrane,pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment,AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form,28-,26-,16-kDa membrane anchored forms,and soluble 21-,19-,and 9-kDa forms .
Supplier Elabscience

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