| Product Name | Amyloid Beta Oligomers (82E1-specific), Human, ELISA Kit |
|---|---|
| Description | Alzheimer's disease (AD) is a neurodegenerative disease which Amyloid beta (Ab) peptide accumulates in a brain and the predominant symptom is a decline of cognitive functions. It has been generally thought that Ab which condenses and become insoluble fiber (fibril) forms the senile plaque and this denatures neurons and develops the symptoms of the disease. (This is called the 'amyloid hypothesis'.) However, 'oligomer hypothesis' is becoming potent these days that the disease is developed by decline in cognitive function because of the soluble Ab oligomer which is a middle object of a condensation process has strong synaptic injurious effects. It is reported that when the Ab oligomer which is secreted from the cell or is extracted from AD patient's brain is injected into rat brain, it causes synaptic dysfunction and sturdy memory loss. Moreover, it is also observed that the Ab oligomers are increasing in brains of AD patients compared with healthy individuals. This kit is a solid phase sandwich ELISA. The primary reaction of sample and enzyme labeled antibody is performed on the U-plate for primary incubation, this incubated mixture is added to the precoated plate and the secondary reaction is performed. After washing removal of the elements which were not combined with coating antibodies, Tetra Methyl Benzidine (TMB) is used as a coloring agent (Chromogen). The strength of coloring reflects the amount of molecules which bind to anti-human Ab (N) (82E1) mouse monoclonal antibodies, recognize the N-terminus of human Ab specifically, with two or more epitopes. Measurement result is calculated in molarity as a relative value standardized on dimers of Ab(1-16). |
| Reactivity | Human |
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