| Product Name | Angiotensin (1-7) |
|---|---|
| Description | Angiotensin (1-7) is an endogenous peptide fragment and key component of the renin-angiotensin system (RAS). It is created from the conversion of angiotensin II (Ang II) into angiotensin (1–7) by angiotensin converting enzyme 2 (ACE2) and acts through activation of the non-AT1, non-AT2 receptor Mas. There are numerous examples of the effects of angiotensin (1–7) in the cardiovascular system where it counteracts the vasoconstrictive and proliferative effects of angiotensin II and also stimulates vasopressin release in vivo. |
| Synonyms | 51833-78-4, ACE, Ang II, Angiotensin (1-7), DRVYIHP, NR-160, NR-160,NR160, RAS, angiotensin II, angiotensin converting enzyme 2, endogenous peptide fragmen, renin-angiotensin system |
| Molecular Weight | 899 Da |
| Target | Angiotensin receptors |
| Amino Acid Sequence | DRVYIHP |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 51833-78-4 |
| Storage | Store frozen, dark and desiccated |
| Notes | Modifications: None |
| References |
Santos et al (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc.Natl.Acad.Sci.U.S.A. 100 8258 PMID: 12829792Santos (2014) Angiotensin-(1-7) Hypertension 63(6) 1138 PMID: 24664288Patel et al (2016) Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure. Circulation Res. 118(8) 1313 PMID: 27081112 Related areasAll peptides >All angiotensin receptor modulators >All endocrinology research categories >All cardiovascular research categories > |
| Supplier | Isca Biochemicals Limited |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
