| Product Name | ANO1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ANO1 |
| Synonyms | ANO 1 antibody; ANO1 antibody; ANO1_HUMAN antibody; Anoctamin 1 antibody; Anoctamin 1 calcium activated chloride channel antibody; Anoctamin-1 antibody; Anoctamin1 antibody; Ca2+ activated Cl- channel antibody; Calcium Activated Chloride Channel antibody; Discovered on gastrointestinal stromal tumors protein 1 antibody; DOG 1 antibody; DOG1 antibody; FLJ10261 antibody; Membrane protein antibody; Oral cancer overexpressed 2 antibody; Oral cancer overexpressed protein 2 antibody; ORAOV 2 antibody; ORAOV2 antibody; TAOS 2 antibody; TAOS2 antibody; TMEM 16A antibody; TMEM16A antibody; Transmembrane protein 16A (eight membrane spanning domains) antibody; Transmembrane protein 16A antibody; Tumor amplified and overexpressed sequence 2 antibody; Tumor-amplified and overexpressed sequence 2 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human ANO1 |
| Isotype | IgG |
| Target | ANO1 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC, WB |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | Q5XXA6 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | TMEM16A, also known as DOG1, ORAOV2, TAOS2 or ANO1 (anoctamin 1), is a 986 amino acid multi-pass membrane protein that localizes to both the cell membrane and the cytoplasm and belongs to the anoctamin family. Expressed in a variety of tissues with highest expression in skeletal muscle and liver, TMEM16A functions as a calcium-activated chloride channel that is required for normal tracheal development. Human TMEM16A shares 90% sequence identity with its mouse counterpart, suggesting a conserved role between species. TMEM16A is present in breast, pancreatic, gastric, and uterine cancers, as well as in neck, ovarian and parathyroid tumors, suggesting a role for TMEM16A in carcinogenesis. Three isoforms of TMEM16A exist due to alternative splicing events. |
| Supplier | Cusabio |
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