| Product Name | Anti-26S Proteasome 20S cylinder particle Monoclonal Antibody |
|---|---|
| Description | The 26S proteasome is a 2.5-MDa molecular machine built from approximately 31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. The regulatory complexes are also implicated in unfolding and translocation of ubiquitinated targets into the interior of the 20S complex, where they are degraded to oligopeptides. Mouse Monoclonal Antibody to 26S Proteasome, 20S cylinder particle (p32 subunit). Polypeptide reacting: p32 subunit of 20S cylinder particles |
| Synonyms | p32 |
| Clonality | Monoclonal |
| Clone | P32 (26S-161) |
| Immunogen | 26S complexes of Xenopus laevis oocytes |
| Isotype | IgG1 |
| Specificity | Recognizes the 20S subcomplex within the 26S hetero- oligomeric protein complex and the free cytosolic form of 20S cylinder particles; the epitope is resistant to formaldehyde fixation (up to 4%). P32 (26S-161) is not suitable for immunoprecipitation. |
| Reactivity | Amphibian, Human, Mouse, Rat |
| Applications | IF |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Peters, J.M. et al. (1994) J. Biol. Chem. 269: 7708-7718Peters, J.M.: Proteasomes: protein degradation machines of the cell. TIBS, 19, September 1994 |
| Background | The 26S proteasome is a 2.5-MDa molecular machine built from approximately 31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. The regulatory complexes are also implicated in unfolding and translocation of ubiquitinated targets into the interior of the 20S complex, where they are degraded to oligopeptides. |
| Supplier | ARP |
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